Peer-reviewed veterinary case report
Hair loss in Pomeranians and poodles treated with trilostane
By Cerundolo, Rosario et al.·Published in Veterinary dermatology·2004·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Treatment of canine Alopecia X with trilostane.
- Species:
- dog
Plain-English summary
Sixteen Pomeranians and eight miniature poodles with hair loss due to alopecia X were treated with a medication called trilostane. After starting treatment, 85% of the Pomeranians and all of the miniature poodles saw their hair fully regrow within 4 to 8 weeks, and there were no side effects from the medication. The treatment seemed to work by lowering certain hormones that affect hair growth. If your dog is experiencing hair loss, trilostane could be a treatment option worth discussing with your vet.
People also search for: dog hair loss treatment · Pomeranian alopecia X · trilostane for dogs · miniature poodle hair regrowth · why is my dog losing hair
Abstract
Sixteen Pomeranians and eight miniature poodles presenting with clinical signs of alopecia X, elevated blood concentrations of 17-hydroxyprogesterone post stimulation with adrenocorticotropic hormone and increased urinary cortisol/creatinine ratios were treated with trilostane, a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. Trilostane was given once or twice daily at a mean dose of 10.85 mg kg(-1) day(-1). Adrenal function was evaluated with a follow-up of 28 months in the Pomeranians and 33 months in the miniature poodles. Treatment with trilostane led to complete hair re-growth in 85% of the Pomeranians and in all of the miniature poodles within 4 to 8 weeks. No adverse events attributed to treatment with trilostane were recognized. The hair re-growth might have been the result of a down-regulation of adrenal steroids and/or of the noncompetitive inhibition of the oestrogen receptors at the hair follicle level.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15500480/