Peer-reviewed veterinary case report
Stem cell extract treatment for dog pancreatitis and inflammation
By Choi, Yongsoo et al.·Published in Frontiers in Veterinary Science·2025·View original on Crossref →
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Original publication title: Treatment of canine pancreatitis using membrane-free stem cell extract and its anti-inflammatory effect
- Species:
- dog
Plain-English summary
A group of 145 dogs with pancreatitis, a painful condition that can cause serious digestive issues, were treated to see if a new therapy could help. Sixty-three of the dogs received a special treatment called membrane-free stem cell extract (MF-STEM) along with standard care, while the other 82 only received the usual treatment. The results showed that 92% of the dogs receiving MF-STEM survived, compared to only 46% in the control group. There were no side effects reported from the new treatment, suggesting it could be a promising option for dogs suffering from pancreatitis.
People also search for: dog pancreatitis treatment · stem cell therapy for dogs · canine pancreatitis survival rate
Abstract
Canine pancreatitis can lead to the digestion of nearby organs, and if untreated, it can develop into peritonitis. Widely used treatment as of now for acute pancreatitis (AP), however, largely depends on supportive treatment such as fluid therapy, antibiotics, and sufficient nutrient intake. Membrane-free stem cell extract (MF-STEM) is a protein mixture and other bioactive molecules derived from human adipose stem cells. MF-STEM is known for its anti-inflammatory and regenerative effects. This study was a vehicle-controlled clinical study. One hundred and forty-five canine pancreatitis patients with pancreatitis participated in this study with owners’ consent. Following the owners’ consent, 63 dogs received MF-STEM cell therapy with conventional therapy, and 82 dogs received conventional therapy. All participants had their cPL and CRP measured to evaluate their clinical progression. At the time of discharge, the survival rate in the MF-STEM cell therapy group survived (survival 92% and mortality 8%) more than the control group (survival 46% and mortality 54%). The authors suppose that MF-STEM cell increases survival of pancreatitis patients by modulating inflammatory cytokines. There were no side effects observed, such as allergic reactions and hypersensitivity reactions.
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Search related cases →Original publication on Crossref: https://doi.org/10.3389/fvets.2025.1590703