Peer-reviewed veterinary case report
Treating pyometra in dogs with acyline hormone blocker and antibiotics
By Batista, Pablo R et al.·Published in Topics in companion animal medicine·2015·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Treatment of canine pyometra with the gonadotropin-releasing hormone antagonist acyline: a case series.
- Species:
- dog
Plain-English summary
A group of four female dogs with a serious uterine infection called pyometra were treated with a hormone blocker called acyline and antibiotics. Within three days, all the dogs showed improvement in their symptoms, and one dog even had a significant change in her condition just 36 hours after treatment. The treatment also helped reduce the size of the uterus in those with high progesterone levels before starting. Importantly, there were no side effects noted from the treatment, suggesting that acyline could be a good option for managing this condition in dogs.
People also search for: dog pyometra treatment · acyline for dogs · female dog uterine infection · symptoms of pyometra in dogs
Abstract
To describe the effect of the third-generation gonadotropin-releasing hormone antagonist acyline in the treatment of 4 diestrous bitches with the cystic endometrial hyperplasia-pyometra complex. The 4 bitches were treated with 330 μg/kg of subcutaneous acyline on day 0 and antibiotics, and followed up for 2 weeks. One closed-cervix case showed cervical dilatation 36 hours after treatment, and all the 4 animals showed resolution of clinical signs starting on day 3 posttreatment. Ultrasonographic uterine diameters and luminal contents decreased in the bitches having high progesterone serum concentrations before treatment but not in those with low levels. Serum progesterone importantly decreased from high to basal concentrations in the 3 "ultrasonographically cured" animals. No local or systemic side effects related to the treatment were observed. The gonadotropin-releasing hormone antagonist acyline may have a promising place for the medical treatment of cystic endometrial hyperplasia-pyometra complex in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26041594/