Peer-reviewed veterinary case report
Dog treated with plasma exchange after carprofen overdose
By Kjaergaard, Astrid B et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2018·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Treatment of carprofen overdose with therapeutic plasma exchange in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old female Bichon Frise was brought to the vet after accidentally swallowing a large amount of carprofen, a common pain medication for dogs. She showed mild dehydration but no serious kidney issues. The vet induced vomiting and used a treatment called therapeutic plasma exchange (TPE) to help remove the carprofen from her system. This treatment successfully reduced the carprofen levels in her blood by over half within three hours. The dog recovered well after the treatment.
People also search for: dog carprofen overdose treatment · Bichon Frise vomiting · therapeutic plasma exchange for dogs
Abstract
OBJECTIVE: To report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis. SUMMARY: A 6-year-old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg/kg carprofen. Mild dehydration without azotemia and with a urine specific gravity of 1.050 was noted at presentation. Treatment consisted of induction of emesis, symptomatic medical therapy, and TPE. The TPE achieved 1.5 plasma volume exchanges over 3 hours. Blood samples and effluent samples were collected every 30 minutes during TPE and additional blood samples were collected 11 and 35 hours after treatment. Carprofen concentrations in these samples were determined by high-pressure liquid chromatography. A 51% reduction in serum carprofen concentration was achieved following TPE. NEW OR UNIQUE INFORMATION PROVIDED: This report describes the successful reduction of plasma carprofen concentration in a dog using TPE. Although recent studies suggest that this particular dog may not have received a toxic dose, a 51% reduction of plasma carprofen concentration was achieved over 180 minutes, and TPE may be beneficial for treatment of dogs that have ingested higher doses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29898245/