Peer-reviewed veterinary case report
Dog's corneal cancer treated successfully with 1% 5-fluorouracil
By Dorbandt, Daniel M et al.·Published in Veterinary ophthalmology·2016·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Treatment of corneal squamous cell carcinoma using topical 1% 5-fluorouracil as monotherapy.
- Species:
- dog
Plain-English summary
A 12-year-old male pug was brought in for a pale pink, raised mass on his right eye, which was diagnosed as corneal squamous cell carcinoma (SCC) after a biopsy. The vet treated the dog with a topical chemotherapy ointment called 5-fluorouracil, applying it four times a day for two weeks, then taking a break for two weeks, and continuing with twice-daily applications for another two weeks. Remarkably, the pug's eye remained clear of any recurrence for 10 months after finishing the treatment. This approach appears to be a safe and effective option for treating this type of eye cancer in dogs.
People also search for: pug eye cancer treatment · corneal squamous cell carcinoma in dogs · 5-fluorouracil for dog eye problems
Abstract
The purpose of this report is to discuss the use of topical 1% 5-fluorouracil as a sole therapy for canine corneal squamous cell carcinoma (SCC). A 12-year-old castrated male pug was evaluated for a well-demarcated, central, 3 mm in diameter, pale pink, raised, right corneal mass. An incisional biopsy was obtained using a #64 beaver blade after topical anesthesia and without sedation. A definitive diagnosis of corneal SCC was obtained after histopathologic evaluation of the biopsy. Topical 1% 5-fluorouracil ointment was applied to the right eye four times daily for 2 weeks followed by no treatment for 2 weeks, then treatment again twice daily for 2 weeks. The cornea remained free of recurrence 10 months after cessation of treatment. In dogs affected with corneal SCC, topical 1% 5-fluorouracil monotherapy may be a viable and cost-effective treatment option with minimal side effects. This chemotherapy agent may also have an effect on corneal pigmentation. Chronic cyclosporine therapy did not contribute to the pathogenesis of corneal SCC in the case described.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26073299/