Peer-reviewed veterinary case report
Chemotherapy with doxorubicin, carboplatin, and piroxicam for nasal
By Langova, V et al.·Published in Australian veterinary journal·2004·University of Queensland, Australia·View original on PubMed →
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Original publication title: Treatment of eight dogs with nasal tumours with alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam.
- Species:
- dog
Plain-English summary
Eight dogs with nasal tumors were treated with a combination of chemotherapy drugs, doxorubicin and carboplatin, along with oral piroxicam, to see how well it worked and if there were any side effects. After just one to two doses, all the dogs showed improvement in their symptoms, and follow-up scans revealed that four dogs had no signs of the tumor, while two had a partial response and two remained stable. Overall, the treatment was effective and well tolerated, giving hope for dogs diagnosed with nasal tumors.
People also search for: dog nasal tumor treatment · chemotherapy for dogs · doxorubicin side effects in dogs
Abstract
OBJECTIVE: To determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours. DESIGN: Retrospective clinical study PROCEDURE: Eight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments. RESULTS: Complete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs. CONCLUSIONS: This chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15977611/