Peer-reviewed veterinary case report
Ezetimibe lowers cholesterol in dogs with high cholesterol
By Oda, Hitomi et al.·Published in The Journal of veterinary medical science·2024·School of Veterinary Nursing & Technology, Japan·View original on PubMed →
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Original publication title: Treatment of Ezetimibe lowers total and low-density lipoprotein cholesterol in hypercholesterolemic dogs with hyperadorenocorticism.
- Species:
- dog
Plain-English summary
Nine dogs with high cholesterol levels were treated with a medication called ezetimibe to help lower their cholesterol. After two and four months of treatment, the dogs showed significant reductions in both total cholesterol and low-density lipoprotein cholesterol (LDL), which is often referred to as "bad" cholesterol. By the end of the study, the dogs had cholesterol levels below the recommended threshold, indicating that ezetimibe was effective in managing their condition. This suggests that ezetimibe could be a helpful option for dogs with high cholesterol.
People also search for: dog high cholesterol treatment · ezetimibe for dogs · lowering dog cholesterol levels
Abstract
Ezetimibe is a cholesterol absorption inhibitor that blocks the intestinal absorption of both biliary and dietary cholesterol, thereby lowering primarily low density lipoprotein-cholesterol (LDL-chol) in human studies. This study aimed to investigate the effects of ezetimibe on dyslipidemia control in nine dogs with hypercholesterolemia. Changes in total cholesterol (T-chol) and each lipoprotein fractions were evaluated at 0, 2, and 4 months following initiation of ezetimibe treatment. A significant decrease in T-chol was observed, and a mean T-chol concentration below 400 mg/dL was achieved at 2 and 4 months. Furthermore, a significant decrease in LDL-chol was observed (-53.3% and -64.3% at 2 and 4 months, respectively). Taken together, treatment of ezetimibe could lower LDL-chol levels in dogs with hypercholesterolemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38383002/