Peer-reviewed veterinary case report
Dog coma from ibuprofen overdose treated with charcoal hemoperfusion
By Tauk, Barbara S & Foster, Jonathan D·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2016·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Treatment of ibuprofen toxicity with serial charcoal hemoperfusion and hemodialysis in a dog.
- Species:
- dog
Plain-English summary
A dog ingested a dangerous amount of ibuprofen and showed severe symptoms, including neurological issues that led to a coma. The veterinarians used a combination of charcoal hemoperfusion and hemodialysis to remove the ibuprofen from the dog's system. Thankfully, this treatment completely reversed the dog's neurological problems, and there was no damage to the kidneys or liver. The dog recovered well after the treatment, confirming that this method was effective for ibuprofen toxicity.
People also search for: dog ibuprofen poisoning treatment · dog coma after ibuprofen · charcoal hemoperfusion for dogs · hemodialysis for dog toxicity
Abstract
OBJECTIVE: To describe the efficacy of serial charcoal hemoperfusion and hemodialysis in removing ibuprofen from a dog with severe clinical signs of toxicity. CASE SUMMARY: A dog ingested a minimum of 2,200 mg/kg of ibuprofen resulting in progressive neurologic dysfunction that progressed to a comatose state by the time of presentation. Extracorporeal charcoal hemoperfusion coupled serially with hemodialysis was performed to remove ibuprofen from this patient. Serial charcoal hemoperfusion and hemodialysis therapy resulted in complete reversal of the neurologic dysfunction in this dog. No evidence of acute kidney or hepatic injury was observed. Serum ibuprofen concentrations confirmed the efficacy of this treatment. NEW INFORMATION PROVIDED: This report details the technique for extracorporeal extraction of ibuprofen, a methodology that could be employed for other toxicities due to substances with similar pharmacokinetics. Complications and limitations (eg, saturation of the charcoal cartridge) of the therapy are discussed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27669490/