Peer-reviewed veterinary case report
Springer Spaniel insulinoma treated with streptozotocin and steroids
By Bell, R et al.·Published in The Journal of small animal practice·2005·Department of Small Animal Clinical Studies, United Kingdom·View original on PubMed →
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Original publication title: Treatment of insulinoma in a springer spaniel with streptozotocin.
- Species:
- dog
Plain-English summary
An 8-year-old female springer spaniel was diagnosed with insulinoma, a type of tumor that causes low blood sugar. She was treated with a medication called streptozotocin, along with corticosteroids, which helped resolve her low blood sugar but later led to diabetes. Unfortunately, the cancer spread and caused her pain, leading to her being euthanized 118 days after treatment. While streptozotocin can be effective for insulinoma, responses can vary widely among dogs.
People also search for: springer spaniel insulinoma treatment · dog low blood sugar symptoms · streptozotocin for dogs
Abstract
An eight-year-old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre- and post-treatment diuresis. A tapering dose of corticosteroids was also administered over a 28 day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN can be safely used for the treatment of canine insulinoma, but, when compared with other published cases, a marked variation in clinical response to this drug exists and further study is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15909449/