Peer-reviewed veterinary case report
Higher radiation dose for brain tumors in dogs improves outcome
By Chris Staudinger et al.·Published in Journal of Veterinary Internal Medicine·2022·Division of Radiation Oncology, Vetsuisse Faculty University of Zurich Zurich Switzerland, GB·View original on DOAJ →
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Original publication title: Treatment of intracranial neoplasia in dogs using higher doses: A randomized controlled trial comparing a boosted to a conventional radiation protocol
- Species:
- dog
Plain-English summary
A group of 57 dogs with brain tumors received either a standard radiation treatment or a higher dose protocol to see if it would improve their condition. While some dogs experienced mild side effects, there were no severe complications, and both treatment methods resulted in similar outcomes. The average time before the tumors progressed was about 708 days, and the overall survival time was around 684 days, showing that increasing the radiation dose did not lead to better results. Pet owners can feel reassured that both treatment options are safe and effective for managing brain tumors in dogs.
People also search for: dog brain tumor treatment · radiation therapy for dogs · dog cancer survival rates
Abstract
Abstract Background Local progression of intracranial tumors can be the consequence of insufficient radiation dose delivered. Dose increases in the brain must be made carefully so as not to risk debilitating adverse effects such as radiation necrosis. Hypothesis A new protocol with 10 × 4 Gy + 11% physical dose increase limited to the macroscopic tumor volume results in a clinically better outcome compared to a 10 × 4 Gy protocol. Animals Fifty‐seven client‐owned dogs with primary intracranial neoplasia. Methods Randomized controlled trial. Twenty‐eight dogs were assigned to the control protocol (10 × 4 Gy) and 29 to the simultaneous integrated boost (SIB) protocol with 4.45 Gy dose increase. Treatment groups were compared for outcome and signs of toxicity. Results Mild, transient acute or early‐delayed adverse radiation effects were observed in 5 dogs. Severe late adverse effects were not seen. Between the protocols, no significant differences were found for outcome (intention‐to‐treat analysis): overall time to progression (TTP) was 708 days (95% confidence interval (95% CI) [545,872]), in the control group it was 828 days (95% CI [401,1256]), and in the SIB group 627 days (95% CI [282,973]; P = .07). Median overall survival (OS) was 684 days (95% CI [516,853]), in the control group it was 724 days (95% CI [623,826]), and in the SIB group 557 days (95% CI [95,1020]; P = .47). None of the tested variables was prognostic in terms of outcome. Conclusion and Clinical Importance The dose escalation used with an 11% physical dose increase did not result in better outcome.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1111/jvim.16472