Peer-reviewed veterinary case report
Treatment of mycotic rhinitis with itraconazole in three horses.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 1994
- Authors:
- Korenek, N L et al.
- Affiliation:
- Department of Rural Practice
- Species:
- horse
Plain-English summary
In a study involving three horses with stubborn fungal infections in their noses, researchers tested a medication called itraconazole. Two of the horses had infections caused by a type of fungus called Aspergillus, while the third horse had a different fungal infection. They were treated with itraconazole for about 3 to 4.5 months, and no side effects were observed during this time. The treatment successfully cleared the fungal infection in both horses with Aspergillus, but the horse with the other type of infection did not improve and still had signs of the infection after treatment. Overall, itraconazole worked well for the Aspergillus infections, but it did not help the horse with the Conidiobolus infection.
Abstract
Itraconazole, a third-generation azole, was evaluated for treatment of resistant nasal mycotic infections in horses. Two horses with Aspergillus spp nasal granulomas and 1 horse with Conidiobolus coronatus nasal infection were treated with itraconazole (3 mg/kg PO bid). One of the horses with nasal aspergillosis was also treated by surgical resection of the nasal septum. The treatment time for the horses ranged from 3 to 4.5 months. No adverse effects were noted in any of the horses during the treatment period. Peak and trough serum itraconazole concentrations were < 0.5 micrograms/mL in all 3 horses. Itraconazole (3 mg/kg PO bid) appears to be effective in the treatment of nasal Aspergillus spp infections in horses because the fungal infection was eliminated in both horses. One horse still had excessive nasal sounds during exercise and was retired from training, whereas the other horse returned to normal. The nasal C. coronatus infection appeared resistant to itraconazole treatment in the affected horse because the granulomas were still present after 4.5 months of treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8064660/