Peer-reviewed veterinary case report
Dog treated with plasma exchange for naproxen overdose
By Kelsea A. Studer & Christine Iacovetta·Published in Journal of Veterinary Internal Medicine·2025·View original on Semantic Scholar →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Treatment of Naproxen Overdose Using Therapeutic Plasma Exchange and Plasmaperfusion in a Dog
- Species:
- dog
Plain-English summary
An 8-year-old male mixed breed dog was brought in after eating a large amount of naproxen, a pain reliever that can be toxic to pets. The veterinarians used a combination of treatments called therapeutic plasma exchange and plasmaperfusion to help remove the drug from his system. After four days in the hospital, the dog showed improvement and was discharged with normal test results, although he did experience some mild stomach issues during treatment. Overall, the treatments helped lower the naproxen levels in his blood, allowing him to recover successfully.
People also search for: dog naproxen overdose treatment · mixed breed dog stomach issues · how to treat dog medication poisoning
Abstract
An 8‐year‐old male neutered 37.4 kg mixed breed dog was presented for suspected ingestion of a large amount of naproxen (estimated at 235–294 mg/kg). The dog was treated using a combination of therapeutic plasma exchange (TPE) and plasmaperfusion (PP). The exchange of 2 plasma volumes during 140 min of TPE resulted in a 46% decrease in blood naproxen concentration. Treatment of 1 plasma volume during the following 90 min of PP resulted in an additional 10.3% decrease in naproxen concentration. The patient developed mild gastrointestinal (GI) signs that were treated medically and was successfully discharged after 4 days of hospitalization with normal follow‐up laboratory test results and physical examination findings. The combination of extracorporeal treatments decreased the plasma concentration of naproxen, but the additional decrease from PP may not have provided substantial benefit compared with other conventional treatments. No reports of PP, as an alternative to hemoperfusion (HP), in veterinary medicine currently are available.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/40884779