Peer-reviewed veterinary case report
Dog treated with plasma exchange after naproxen overdose
By Studer, Kelsea A & Iacovetta, Christine·Published in Journal of veterinary internal medicine·2025·Red Bank Veterinary Hospital, United States·View original on PubMed →
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Original publication title: Treatment of Naproxen Overdose Using Therapeutic Plasma Exchange and Plasmaperfusion in a Dog.
- Species:
- dog
Plain-English summary
An 8-year-old male mixed breed dog was brought to the vet after eating a large amount of naproxen, a pain reliever that can be toxic to dogs. The vet used a combination of two advanced treatments, therapeutic plasma exchange and plasmaperfusion, to help remove the drug from the dog's system. After a few days in the hospital, the dog showed some mild stomach issues but was treated and eventually discharged with normal health check results. This case highlights how specialized treatments can help manage medication overdoses in pets.
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Abstract
An 8-year-old male neutered 37.4 kg mixed breed dog was presented for suspected ingestion of a large amount of naproxen (estimated at 235-294 mg/kg). The dog was treated using a combination of therapeutic plasma exchange (TPE) and plasmaperfusion (PP). The exchange of 2 plasma volumes during 140 min of TPE resulted in a 46% decrease in blood naproxen concentration. Treatment of 1 plasma volume during the following 90 min of PP resulted in an additional 10.3% decrease in naproxen concentration. The patient developed mild gastrointestinal (GI) signs that were treated medically and was successfully discharged after 4 days of hospitalization with normal follow-up laboratory test results and physical examination findings. The combination of extracorporeal treatments decreased the plasma concentration of naproxen, but the additional decrease from PP may not have provided substantial benefit compared with other conventional treatments. No reports of PP, as an alternative to hemoperfusion (HP), in veterinary medicine currently are available.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40884779/