Peer-reviewed veterinary case report
Treatment results for dogs with resistant and non-resistant Staph
By Bryan, Jacqueline et al.·Published in Veterinary dermatology·2012·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Treatment outcome of dogs with meticillin-resistant and meticillin-susceptible Staphylococcus pseudintermedius pyoderma.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections caused by either meticillin-resistant or meticillin-susceptible Staphylococcus pseudintermedius were treated with different antibiotics. Most dogs with the susceptible strain responded well to cefalexin or cefpodoxime, while those with the resistant strain were treated with chloramphenicol or doxycycline. While many dogs showed improvement, some experienced side effects, particularly from chloramphenicol, which led to discontinuation in some cases. Overall, most dogs recovered from their infections, although those with the resistant strain sometimes took longer to heal.
People also search for: dog skin infection treatment · meticillin-resistant Staphylococcus in dogs · chloramphenicol side effects in dogs
Abstract
BACKGROUND: The prevalence of meticillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) in canine pyoderma has been increasing in recent years; thus, treatment of these cases has become challenging. HYPOTHESIS/OBJECTIVES: To compare treatment outcome (clinical resolution and treatment duration), adverse effects of medication, and concurrent diseases and medications in dogs with meticillin-susceptible S. pseudintermedius (MSSP) and MRSP pyoderma. ANIMALS/METHODS: Medical records were reviewed retrospectively, and 123 MSSP and 93 MRSP clinical cases between January 2008 and April 2010 were included. RESULTS: In MSSP infections, cefalexin and cefpodoxime were the most commonly prescribed antimicrobials, accounting for 43.2 and 34.4% of cases, respectively. In MRSP infections, chloramphenicol and doxycycline were most commonly prescribed, accounting for 52.6 and 14.4% of cases, respectively. Adverse effects were reported in seven MSSP and 31 MRSP cases. The most commonly reported adverse effects were gastrointestinal, prompting antibiotic discontinuation in three MSSP and 20 MRSP cases. Chloramphenicol was associated with the highest incidence of adverse reactions (27 of 51 cases). Of 164 cases with follow up, 43 of 88 MSSP infections and 29 of 76 MRSP infections achieved complete clinical resolution at the first recheck examination. Three MSSP and seven MRSP cases failed to improve or resolve at subsequent visits assessed at 3-4 week intervals. CONCLUSIONS AND CLINICAL IMPORTANCE: Results from this study showed that the majority of pyodermas resolved regardless of meticillin susceptibility. Although some cases of MRSP pyoderma took longer to treat, this is likely to be because of chronicity and not the organism. In addition, adverse effects were frequently associated with chloramphenicol administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22364681/