Peer-reviewed veterinary case report
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2015
- Authors:
- Rocha-Pereira, Joana et al.
- Affiliation:
- KU Leuven - University of Leuven
Abstract
Prolonged norovirus shedding may occur in certain patients, such as organ transplant recipients. We established a mouse model for persistent norovirus infection (using the mouse norovirus MNV.CR6 strain). The nucleoside viral polymerase inhibitor 2'-C-methylcytidine (2CMC), but not favipiravir (T-705), reduced viral shedding to undetectable levels. Viral rebound was observed after stopping treatment, which was again effectively controlled by treatment with 2CMC. No drug-resistant variants emerged.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26711754/