Peer-reviewed veterinary case report
Treatment with anti-TNF alpha does not induce reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice.
- Journal:
- Scandinavian journal of immunology
- Year:
- 2007
- Authors:
- van Diepen, A et al.
- Affiliation:
- Department of Infectious Diseases · Netherlands
- Species:
- rodent
Abstract
Therapy with tumour necrosis factor-alpha (TNFalpha)-blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNFalpha did not result in reactivation of infection, suggesting only a minor role for TNFalpha during latency of persistent Salmonella infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17444950/