Peer-reviewed veterinary case report
How hydrolyzed diet with prebiotics changes fat metabolism in dogs
By Yoko M. Ambrosini et al.·Published in Frontiers in Veterinary Science·2020·Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States, CH·View original on DOAJ →
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Original publication title: Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) was treated with a special hydrolyzed diet, either alone or combined with prebiotics and glycosaminoglycans (GAGs), for 10 weeks. Owners may notice symptoms like diarrhea or weight loss in their pets. The treatment aimed to improve the dogs' gut health by altering their lipid metabolism, which is important for maintaining healthy cell membranes in the intestines. After the treatment, the dogs showed improvements in certain blood markers, suggesting better gut health and integrity.
People also search for: dog inflammatory bowel disease treatment · hydrolyzed diet for dogs with diarrhea · prebiotics for dog gut health
Abstract
Canine inflammatory bowel disease (IBD) is a chronic, immunologically mediated intestinal disorder, resulting from the complex interaction of genetic, environmental and immune factors. Hydrolyzed diets are used in dogs with food-responsive diarrhea (FRD) to reduce adverse responses to immunostimulatory proteins. Prebiotics (PRBs) and glycosaminoglycans (GAGs) have previously been demonstrated to show anti-inflammatory activity in the intestinal mucosa. Notably, hydrolyzed diets combined with the administration of PRBs and GAGs offer a promising approach for the treatment of canine IBD. Our aim was to investigate the effects of hydrolyzed diet and GAG+PRB co-treatment on the serum metabolomic profile of IBD dogs. Dogs with IBD randomly received either hydrolyzed diet supplemented with GAGs and PRBs (treatment 1) or hydrolyzed diet alone (treatment 2) for 10 weeks. A targeted metabolomics approach using mass spectrometry was performed to quantify changes in the serum metabolome before and after treatment and between treatment 1 and 2. Principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), hierarchical cluster analysis (HCA) and univariate statistics were used to identify differences between the treatment groups. PCA, PLS-DA, and HCA showed a clear clustering of IBD dogs before and after hydrolyzed diet, indicating that the treatment impacted the serum metabolome. Univariate analysis revealed that most of the altered metabolites were involved in lipid metabolism. The most impacted lipid classes were components of cell membranes, including glycerophospholipids, sphingolipids, and di- and triglycerides. In addition, changes in serum metabolites after GAG+PRB co-treatment suggested a possible additional beneficial effect on the lipid metabolism in IBD dogs. In conclusion, the present study showed a significant increase in metabolites that protect gut cell membrane integrity in response to hydrolyzed diet alone or in combination with GAG+PRB co-treatment. Administration of such treatment over 70 days improved selected serum biomarkers of canine IBD, possibly indicating improved intestinal membrane integrity.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2020.00451