Peer-reviewed veterinary case report
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
- Journal:
- Nature reviews. Genetics
- Year:
- 2008
- Authors:
- Gondo, Yoichi
- Affiliation:
- Mutagenesis and Genomics Team · Japan
Abstract
The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins and rationale of these large-scale mouse mutagenesis programmes.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18781157/