Peer-reviewed veterinary case report
Trichohyalin gene drops as dog dermatitis gets worse
By Marsella, Rosanna et al.·Published in Frontiers in veterinary science·2024·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Trichohyalin gene expression is negatively correlated with the severity of dermatitis in a canine atopic dermatitis model.
- Species:
- dog
Plain-English summary
A dog with atopic dermatitis, a skin condition caused by allergies, was studied to see how exposure to house dust mites affected the severity of its symptoms. Researchers found that a specific protein related to skin health, called trichohyalin, decreased significantly as the dermatitis worsened. In contrast, another protein associated with skin irritation increased during the study. This suggests that changes in these proteins could help explain how atopic dermatitis develops and worsens in dogs. Further research may help improve treatments for this common allergy-related skin issue.
People also search for: dog skin allergies treatment · atopic dermatitis in dogs · house dust mites dog allergy
Abstract
INTRODUCTION: Canine atopic dermatitis (AD) closely mimics human AD and is recognized as a beneficial animal model. House dust mites (HDM) are a common allergen for both species. The effects of chronic exposure to HDM on the skin have not been studied in this animal model, and it is not known how changes in gene expression correlate to the severity of dermatitis. METHODS: We used an established canine model of AD and took biopsies before HDM exposure (D0) and five times during repeated allergen challenges (on Days 1, 2, 8, 15, and 29, hereafter referred to as D1, D2, D8, D15, and D29). The severity of dermatitis was scored on the same days. RESULTS: Trichohyalin () gene expression decreased the most (15-fold decrease on D29 vs. D0) and negatively correlated with the severity of dermatitis. Gap-junction protein gene expression increased over 3-fold on D1, D8, and D29 and positively correlated with the severity of dermatitis. Compared to D0, IL-31 gene expression significantly increased on D8 ( = 0.0098), D15 ( = 0.0068), and D29 ( = 0.0187), but the correlation with the severity of dermatitis did not reach significance. DISCUSSION: This is the first report on trichohyalin, a protein belonging to the S100 family, and gap-junction protein gene expression in the context of the clinical severity of AD. We propose that these proteins should be further investigated to better understand their role in this complex disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39234173/