Peer-reviewed veterinary case report
Trilostane treatment helps cats with pituitary hyperadrenocorticism
By Neiger, Reto et al.·Published in Journal of veterinary internal medicine·2004·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats.
- Species:
- cat
Plain-English summary
Five cats with a rare condition called hyperadrenocorticism (which causes excessive cortisol production) were treated with a medication called trilostane. All cats were diagnosed through specific tests, and three of them also had diabetes. While trilostane helped reduce some symptoms and improved test results, the cats still showed signs of the condition and their insulin needs didn't change. Unfortunately, two of the cats passed away within a few months, but three others were still alive 6 to 20 months after starting the treatment. More studies are needed to determine the best use of trilostane for this condition.
People also search for: cat hyperadrenocorticism treatment · trilostane for cats · signs of high cortisol in cats
Abstract
Hyperadrenocorticism is a rare syndrome in cats. Current medical therapy is unsatisfactory and prognosis for long-term survival with surgical treatment is guarded. We report on 5 cats treated with the 3-beta hydroxysteroid dehydrogenase inhibitor trilostane. Diagnosis was confirmed in all cats by endocrine testing. Three cats had concurrent diabetes mellitus. Trilostane reduced clinical signs and improved endocrine test results in all cats, but insulin requirements did not change and all continued to have some signs of hypercortisolemia. Two died or were euthanized after 16 and 140 days, whereas 3 were still alive 6, 11, and 20 months after the start of trilostane therapy. Trilostane ameliorates clinical signs of feline hyperadrenocorticism, but more research is needed before it can be recommended for treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15058766/