Peer-reviewed veterinary case report
Female dogs with trisomy-X and abnormal heat cycles
By O'Connor, C L et al.·Published in Theriogenology·2011·School of Veterinary Medicine, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Trisomy-X with estrous cycle anomalies in two female dogs.
- Species:
- dog
Plain-English summary
Two female dogs were brought in because they had irregular heat cycles and were unable to get pregnant despite multiple attempts to breed. After trying medical treatments that didn’t work, tests showed that both dogs had an unusual genetic condition called trisomy-X, where they had three X chromosomes instead of the usual two. Eventually, both dogs underwent surgery to remove their ovaries and uterus, which revealed underdeveloped ovaries. This case emphasizes the need for genetic testing when diagnosing infertility issues in female dogs.
People also search for: dog infertility causes · female dog heat cycle problems · trisomy-X in dogs · dog ovariohysterectomy recovery
Abstract
Two female dogs were presented with a history of abnormal estrous cycles and infertility, despite multiple breedings. Medical therapy to correct the cycle anomalies did not result in pregnancy. Cytogenetic analysis of blood lymphocyte cultures in each dog revealed three copies of the X chromosome in each cell, constituting a 79,XXX karyotype (trisomy-X). Both dogs were eventually ovariohysterectomised and histological evaluation revealed hypoplastic ovaries and an absence of normal follicular structures. However, partial or immature follicles were noted, which may have been sufficient to cause both females to initiate cycling. The history and clinical characteristics found in these dogs were compared to those described in three other dogs reported with trisomy-X, as well as those reported in other species. These findings highlighted the importance of cytogenetic studies in fertility evaluation and achieving a definitive diagnosis for infertility in the bitch.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21550105/