Peer-reviewed veterinary case report
Tumor-associated macrophages press the angiogenic switch in breast cancer.
- Journal:
- Cancer research
- Year:
- 2007
- Authors:
- Lin, Elaine Y & Pollard, Jeffrey W
- Affiliation:
- Department of Developmental and Molecular Biology · United States
Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17545580/