Peer-reviewed veterinary case report
Tumor lysis syndrome after chemotherapy in a dog with lymphoma
By Piek, C J & Teske, E·Published in Tijdschrift voor diergeneeskunde·1996·View original on PubMed →
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Original publication title: [Tumor lysis syndrome in a dog].
- Species:
- dog
Plain-English summary
A dog with malignant lymphoma developed a serious condition called tumor lysis syndrome after starting chemotherapy. This syndrome occurs when cancer cells break down rapidly, releasing harmful substances into the bloodstream that can cause kidney failure and dangerous heart rhythms. The dog experienced high levels of potassium and phosphorus, which can be life-threatening. To prevent this condition, veterinarians recommend careful monitoring and management during treatment.
People also search for: dog lymphoma chemotherapy side effects · tumor lysis syndrome in dogs · dog kidney failure after cancer treatment
Abstract
The acute tumour lysis syndrome in humans as well as in dogs is caused by the acute lysis of tumour cells following chemotherapy. The release of intracellular products and their metabolites result in hyperkalemia, hyperphosphatemia, and hyperuricemia. The precipitation of uric acid and calciumphosphate in the kidneys can lead to hypocalcemia and acute renal failure which leads to fatal azotemia and arrhythmia's due to electrolyte disturbances. In this article the occurrence of the acute tumour lysis syndrome in a dog with malignant lymphoma is described. Suggestions to prevent the tumour lysis syndrome are made.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8711720/