Peer-reviewed veterinary case report
p53 gene mutation found in dog haemangiosarcoma tumor
By Mayr, B et al.·Published in Acta veterinaria Hungarica·2002·Institute for Animal Breeding and Genetics·View original on PubMed →
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Original publication title: Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog.
- Species:
- dog
Plain-English summary
A dog with a type of cancer called hemangiosarcoma had a mutation in a gene known as p53, which helps prevent tumors. Researchers found a specific deletion in this gene that could be linked to the cancer. Understanding these genetic changes can help veterinarians better diagnose and treat this serious condition in dogs.
People also search for: dog hemangiosarcoma treatment · p53 mutation in dogs · dog cancer gene testing
Abstract
Haemangiosarcomas of dogs were analysed by molecular genetic techniques. Regions of the tumour suppressor gene p53, including the well-known tumour hot spots (codons 175, 245, 248, 249, 273 and 282) were screened. A 24 bp deletion was detected in exon 5 of the gene.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12113170/