Peer-reviewed veterinary case report
Genes on chromosome 5 linked to allergy IgE levels in Labradors
By Owczarek-Lipska, Marta et al.·Published in PloS one·2012·Institute of Genetics·View original on PubMed →
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Original publication title: Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.
- Species:
- dog
Plain-English summary
A study found that two specific areas on chromosome 5 are linked to high levels of IgE antibodies in Labrador Retrievers, which are important in allergic reactions. This research involved 161 Labradors and focused on their responses to allergens from certain types of mites that can cause skin allergies, like atopic dermatitis. Understanding these genetic factors may help in managing allergies in dogs better. While no specific gene was identified, this could lead to new insights into how dogs respond to allergens.
People also search for: Labrador retriever allergies · dog skin problems mites · atopic dermatitis treatment in dogs
Abstract
Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22720065/