Peer-reviewed veterinary case report
Two New Triterpenoid Saponins with Antifungal Activity from <i>Camellia sinensis</i> Flowers.
- Year:
- 2025
- Authors:
- Zong JF et al.
- Affiliation:
- Anhui Agricultural University · China
Abstract
Two new triterpenoid saponins, namely camsinsaponins A and B (<b>1</b>, <b>2</b>), along with two known congeners (<b>3</b>, <b>4</b>) were isolated from <i>Camellia sinensis</i> flowers. Their structures were determined by extensive spectroscopic data. All compounds were assessed for antifungal bioactivity against <i>Candida albicans</i>, <i>Candida glabrata</i>, and <i>Candida tropicalis</i>. Compounds <b>1</b>-<b>4</b> showed excellent inhibitory effects. Notably, in regard to compounds <b>1</b> and <b>2</b>, their MIC values against <i>C. albicans</i> were close to those of the positive control, fluconazole. Furthermore, the inhibitory elements of compounds <b>1</b>-<b>4</b> on <i>C. glabrata</i> were better than those of fluconazole. The aforementioned findings offer valuable insights for future development of novel therapeutic strategies against drug-resistant infections.
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Search related cases →Original publication: https://europepmc.org/article/MED/39940914