Ultra-flexible Coil for Wireless Endovascular Cortical Stimulation.

Abstract

Endovascular devices hold promise for minimally invasive neural stimulation, particularly for applications in the treatment of neurological disorders. We developed a fully wireless endovascular neural stimulator with a novel coil design implemented on a mesh structure to achieve ultra-flexibility. The device was successfully implanted into the superior sagittal sinus of a sheep model via a minimally invasive catheter procedure, demonstrating its adaptability to curved and narrow cerebral veins. Wireless power transfer efficiency (PTE) was analyzed theoretically, simulated, and validated through benchtop and animal experiments. Neural stimulation achieved using pulse-modulation from external transmitter was also validated. This work demonstrates the feasibility of a wireless endovascular device for cortical neural stimulation, paving the way for future advancements in flexible, minimally invasive neural interfaces.Clinical Relevance-This wireless endovascular neural stimulator avoids the risk of open-skull surgery, as well as the risk of endothelial cell responses and wire wear associated with wired endovascular devices. Compatibility with standard neurovascular catheter procedures presents a promising solution for treating neurological disorders like paralysis and epilepsy.