Peer-reviewed veterinary case report
Kidney blood flow in female dogs with mammary cancer
By Vargas Estrada, Cristhian Rene et al.·Published in Scientific reports·2021·Faculdade de Ciê, Brazil·View original on PubMed →
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Original publication title: Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen.
Plain-English summary
A group of female dogs with mammary cancer underwent surgery and were then treated with carprofen, a common anti-inflammatory medication, for three months. The study monitored their kidney function and overall health during this time. Results showed that while carprofen did cause some changes in blood tests, it had minimal impact on kidney blood flow and was safe for these dogs. The treated dogs showed improvements in certain blood parameters, indicating that carprofen can be a helpful part of cancer treatment without harming kidney function.
People also search for: dog mammary cancer treatment · carprofen for dogs · kidney function in dogs with cancer
Abstract
The aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for three months after surgery. Twenty-six bitches with mammary carcinoma were equally distributed into TG that received carprofen 4.4 mg/kg/day for 90 days and CG that did not receive anti-inflammatory medication. Renal artery Doppler flowmetry, contrast-enhanced ultrasound (CEUS) of renal parenchyma, haematological, biochemical and clinical analyses were obtained once a month. These data were compared between groups and time via analysis of variance (ANOVA) in a completely randomized design with repeated measures (P < 0.05). On B-mode ultrasound, the area of the renal artery was greater (P = 0.0003) in the TG. Regarding laboratory findings, haematocrit and haemoglobin were similar in both groups, showing a significant and gradual increase after three months of treatment; MCV, MHC, and MCHC were increased (P < 0.05) and lymphocyte and band counts decreased (P < 0.05) in the TG. Regarding biochemical tests, ALT was the only parameter with a significant difference, being higher (P = 0.0272) in the treated group. It can be concluded that the use of carprofen for 90 days causes minimal changes in renal perfusion, erythrocyte parameters and ALT activity, and reduces the proportion of blood inflammatory cells. Therefore, use of this medication can be carried out safely in patients who require auxiliary cancer treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34857853/