Peer-reviewed veterinary case report
Ultrastructural signs of neuroaxonal dystrophy in a Papillon dog brain
By Tanaka, Miyuu et al.·Published in The Journal of veterinary medical science·2017·Graduate School of Life and Environmental Science, Japan·View original on PubMed →
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Original publication title: Ultrastructural features of canine neuroaxonal dystrophy in a Papillon dog.
- Species:
- dog
Plain-English summary
A 5-year-old Papillon was diagnosed with neuroaxonal dystrophy (NAD), a serious nerve disease that causes swelling in the nervous system. The dog showed signs of neurological issues, which led to further testing that revealed damage to nerve cells and their connections. Researchers found that the disease was linked to a specific gene mutation. Unfortunately, there is currently no cure for NAD, and treatment focuses on managing symptoms and providing supportive care.
People also search for: Papillon dog neuroaxonal dystrophy symptoms · dog nerve disease treatment · what is neuroaxonal dystrophy in dogs
Abstract
Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by severe axonal swelling (spheroids) throughout the nervous system. In dogs, NAD has been reported in several breeds and a missense mutation in PLA2G6 gene has recently been identified in the Papillon dog NAD. Here we performed ultrastructural analysis to clarify the detailed ultrastructural features of the Papillon dog NAD. Dystrophic axons consisted of accumulation of filamentous materials, tubulovesicular structures, and swollen edematous mitochondria with degenerated inner membranes were often observed in the central nervous system. At axonal terminals, degeneration of presynaptic membrane was also detected. As reported in Pla2g6 knockout mice, mitochondrial and presynaptic degeneration may be related with the pathogenesis of NAD in Papillon dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28993562/