Peer-reviewed veterinary case report
Ultrastructure of junctional epidermolysis bullosa in Belgian foals.
- Journal:
- Journal of comparative pathology
- Year:
- 1988
- Authors:
- Johnson, G C et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
- Species:
- horse
Plain-English summary
This study looked at a skin condition in Belgian foals that seems to be inherited. It found that the skin layers separate in a specific area, which is similar to a human condition called junctional epidermolysis bullosa. The researchers noted that while the top layer of skin separates, the deeper layer stays attached to the underlying tissue. They also observed some small structures in the nearby healthy skin that are typical of this condition. Overall, the findings help to better understand this skin disease in foals.
Abstract
Ultrastructural examination of a mechanobullous disease of probable hereditary nature in Belgian foals, confirmed light microscopic findings that separation of the dermo-epidermal junction occurred through the lamina lucida of the basement membrane, leaving the intact lamina densa adherent to the dermis and the plasmalemma of the basal epithelial cells intact. The location of the cleft and the presence of small hemidesmosomes in adjacent intact skin are additional characteristics which make this condition similar to junctional epidermolysis bullosa of man.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3204167/