Peer-reviewed veterinary case report
Under pressure: stromal fibroblasts change their ways.
- Journal:
- Cell
- Year:
- 2005
- Authors:
- Bierie, Brian & Moses, Harold L
- Affiliation:
- Department of Cancer Biology and Vanderbilt-Ingram Cancer Center · United States
Abstract
In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16360028/