Unilateral olfactory deficit in a hemiparkinson's disease mouse model.

Abstract

Parkinson's disease is a neurodegenerative disease which often presents hyposmia (80-90% of the cases). We characterized the olfactory behavior in the model of 6-hydroxydopamine of Parkinson's disease. Mice were trained to discriminate between two odorants in a radial maze. One of the odorants was associated with water as a reward. 6-hydroxydopamine was injected directly into the dorsal striatum; after complete striatal denervation, olfactory performance was evaluated in a radial maze. In the first evaluation, experimental mice performed as control mice. After the first evaluation, the narine of the contralateral side to the striatal injection was closed and mice were evaluated again. The experimental group completely lost the capacity to discriminate between the odorant associated with the reward (heptaldehyde) and the unconditioned odorant (2-heptanone). We propose that the olfactory deficit was caused by dopaminergic denervation to the olfactory tubercle and nucleus accumbens.