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Peer-reviewed veterinary case report

Left eye optic nerve underdevelopment causing poor vision in a Beagle

By Negishi, H et al.·Published in Laboratory animals·2008·Kannami Laboratory, Japan·View original on PubMed

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Original publication title: Unilateral optical nerve hypoplasia in a Beagle dog.

Species:
dog

Plain-English summary

A six-month-old male Beagle was found to have poor vision in his left eye due to a condition called optic nerve hypoplasia, which means the optic nerve didn't develop properly. Tests showed that the left eye had a small optic disc and abnormal blood vessels, but the right eye was normal. Despite the issues with the left eye, the dog's overall brain structure looked fine. Unfortunately, there isn't a treatment to fix the hypoplasia, so the dog will likely have permanent vision problems in that eye.

People also search for: Beagle eye problems · dog optic nerve hypoplasia · poor vision in dog treatment

Abstract

Unilateral (left eye) optic nerve hypoplasia was detected in a six-month-old male Beagle dog. Vision testing indicated that the left eye had poor vision and testing the pupillary light reflex showed the left eye to have an absence of the afferent pathway of the reflex but it had a normal efferent pathway. Ophthalmoscopy revealed a small-sized optic disc, winding retinal artery and dilated retinal vasculature in the left globe. Electroretinography showed no abnormal findings even in the left globe. Histopathologically, the left optic nerve was markedly hypoplastic and was composed of sparse neural elements and a moderate amount of connective and glial tissues. In the retina of the left globe, the nerve fibre layer and the ganglion cell layer were reduced in thickness, although a small number of ganglion cells were still present. There were no abnormal findings detected in the right globe and the right optic nerve. The brain appeared normal macroscopically.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18625594/