Peer-reviewed veterinary case report
Dog with unusual skin lump diagnosed by cell and tissue tests
By Russell, Elise B & Courtman, Natalie F·Published in Veterinary clinical pathology·2019·U-Vet Werribee Animal Hospital and Faculty of Veterinary and Agricultural Sciences, Australia·View original on PubMed →
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Original publication title: Unique cytologic and histologic features of a suspected cutaneous xanthoma in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old spayed female American Staffordshire Terrier was brought to the vet with a skin lump that had been growing slowly for a year. After examining the mass and running some tests, the vet found that the lump was made up of specific cells that suggested it might be a type of skin growth called a cutaneous xanthoma, which is related to fat metabolism issues. The mass was completely removed, and further tests confirmed it was a benign growth rather than cancer. The dog is expected to do well after the surgery.
People also search for: dog skin lump treatment · American Staffordshire Terrier skin growth · cutaneous xanthoma in dogs
Abstract
A 4-year-old spayed female American Staffordshire Terrier presented to the U-Vet Animal Hospital, Werribee, Australia, with a cutaneous mass that had been slowly growing over 12 months. Cytologic evaluation showed cohesive to individualized, vacuolated spindled cells often arranged in a perivascular pattern. The mass was completely excised, and the histopathologic examination demonstrated sheets of vacuolated spindled to round cells expanding the full thickness of the dermis. The cells demonstrated both Iba1 and CD18 antibody binding, leading to an initial interpretation of histiocytic sarcoma. Given the discordance with the clinical presentation, further immunohistochemistry (IHC) was performed. The cells demonstrated strong CD204 antibody binding and did not bind E-cadherin antibody, consistent with a dermal macrophage origin. Ki-67 antibody binding was regionally variable from <5% to 25%, with more regions that had low Ki-67 expression. A fasted serum biochemistry panel revealed hypertriglyceridemia and persistent hypercholesterolemia. Based on clinical, microscopic, biochemical, and IHC results, the final interpretation was an indolent dermal histiocytic proliferation of macrophage origin, with a preference for cutaneous xanthoma or reactive dermal fibrohistiocytoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31762089/