Peer-reviewed veterinary case report
Metabolic changes in blood of dogs with hypothyroidism
By Muñoz-Prieto, Alberto et al.·Published in Research in veterinary science·2021·Clinic for Internal Diseases·View original on PubMed →
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Original publication title: Untargeted metabolomic profiling of serum in dogs with hypothyroidism.
- Species:
- dog
Plain-English summary
A group of dogs with hypothyroidism, a condition where the thyroid doesn't produce enough hormones, were studied to understand how their blood chemistry differs from healthy dogs. The researchers found that certain substances in the blood, like D-gluconic acid and L-Isoleucine, were significantly different in dogs with hypothyroidism. These changes could help identify dogs with this condition more easily in the future. While the study focused on understanding the disease better, it highlights the importance of monitoring thyroid health in dogs to improve their quality of life.
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Abstract
Hypothyroidism is one of the most commonly diagnosed endocrine disease in dogs. The clinical signs are caused by a deficiency of the active thyroid hormones triiodothyronine (T3) and thyroxine (T4) and have a negative impact on dog's quality of life. We hypothesized that serum metabolic profile varies between healthy dogs and dogs with hypothyroidism. Twenty serum samples from dogs with hypothyroidism and 20 from healthy dogs were used for untargeted metabolomics analysis performed by LC/MS analysis. Fifteen metabolites showed significant changes between hypothyroid and healthy dogs, being the pentose phosphate pathway (PPP), aminoacyl-tRNA biosynthesis and pyrimidine metabolism the principal pathways altered in hypothyroidism. Specifically, metabolites such as D-gluconic acid and L-Isoleucine may potentially act as biomarkers of disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33550147/