Peer-reviewed veterinary case report
Unusual case of pyogranulomatous hepatitis of suspected infectious etiology in a 3-year-old Labrador retriever dog.
- Journal:
- The Canadian veterinary journal = La revue veterinaire canadienne
- Year:
- 2020
- Authors:
- Ladak, Malika
- Affiliation:
- Ontario Veterinary College · Canada
- Species:
- dog
Plain-English summary
A 3-year-old spayed female Labrador retriever was brought to the vet because she was very tired, vomiting, eating less than usual, and having trouble breathing. The vet performed surgery to look inside her abdomen and took a sample of her liver for testing. The results showed that she had a type of liver inflammation called pyogranulomatous hepatitis, which is often caused by an infection. While tests for a specific infection called leptospirosis came back negative, it’s still possible that it contributed to her condition. Unfortunately, the exact cause of her liver problem was not determined.
Abstract
A 3-year-old spayed female Labrador retriever dog was presented with clinical signs of lethargy, vomiting, hyporexia, and increased respiratory effort. An exploratory laparotomy was conducted and a liver biopsy submitted for histopathologic evaluation revealed moderate multifocal coalescing pyogranulomatous hepatitis. Clinical signs, hematological parameters, and liver histopathology suggested an infectious etiology, such as leptospirosis, mycobacteriosis, or fungal infection. Polymerase chain reaction (PCR) and immunohistochemistry (IHC) for leptospirosis were negative. The infectious etiology was not identified, but leptospirosis may have played a role in the disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32355355/