Peer-reviewed veterinary case report
Dog with multiple bone pain diagnosed with rare IgM multiple myeloma
By Lautzenhiser, Sarah J et al.·Published in Journal of the American Veterinary Medical Association·2003·Affiliated Veterinary Specialists, United States·View original on PubMed →
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Original publication title: Unusual IgM-secreting multiple myeloma in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old male dog was brought in for limping on multiple legs and showed signs of pain when his legs were touched. X-rays showed bone damage, and blood tests indicated high calcium levels. Further testing revealed a rare type of cancer called multiple myeloma, which was confirmed through urine and blood tests. The dog started chemotherapy with melphalan and prednisone, which helped improve his condition, but unfortunately, he was later euthanized due to a broken bone caused by the disease.
People also search for: dog limping multiple myeloma · dog cancer treatment melphalan · signs of bone cancer in dogs
Abstract
A 4-year-old castrated male dog was evaluated because of multiple-limb lameness. Signs of pain were elicited during palpation of the regions of the proximal tibial metaphyses and distal left radial diaphysis. Radiography revealed osteolytic lesions of the long bones. Blood analyses revealed hypercalcemia and transient cytopenias. Serum protein electrophoresis did not reveal a monoclonal gammopathy; however, urine protein electrophoresis revealed Bence Jones proteinuria. Serial diagnostic sampling of bone lesions, immunohistochemical staining methods, and serum and urine protein immunoelectrophoresis were required to establish a diagnosis of multiple myeloma. Two IgM components were identified via serum protein immunoelectrofixation. The dog improved clinically after initiation of chemotherapy with melphalan and prednisone; however, the dog ultimately was euthanatized because of pathologic fracture. The case was unique because there was lack of vertebral involvement, an unusual gammopathy, and difficulty in identifying myeloma cells via serial sampling.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12959382/