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Peer-reviewed veterinary case report

Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.

Journal:
ASN neuro
Year:
2023
Authors:
Zeng, Fei et al.
Affiliation:
Department of Neurology · China
Species:
rodent

Abstract

The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/36683340/