Peer-reviewed veterinary case report
Urinary test supports primary hyperaldosteronism diagnosis in cat
By Koutinas, Christos K et al.·Published in Journal of the American Animal Hospital Association·2015·From the Companion Animal Clinic, Netherlands·View original on PubMed →
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Original publication title: Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat.
- Species:
- cat
Plain-English summary
A 9-year-old cat was brought to the vet because of high blood pressure, which was measured at 290 mm Hg. Tests showed that the cat had high levels of a hormone called aldosterone, suggesting a condition known as primary hyperaldosteronism (PHA). The vet tried to confirm this diagnosis by giving the cat a medication called fludrocortisone and measuring aldosterone levels in the urine, but unfortunately, the cat did not respond well to treatment and passed away before further options could be explored.
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Abstract
A 9 yr old cat was presented with clinical signs and laboratory abnormalities attributed to arterial hypertension (mean systolic arterial pressure, 290 mm Hg). Plasma aldosterone concentration was increased at the time of admission (651 pmol/L), but serum creatinine and potassium concentrations were within the reference range. A second increased aldosterone (879 pmol/L) and normal plasma renin activity (1.85 ng/mL/hr) resulted in an increased aldosterone/renin ratio, which was suggestive of primary hyperaldosteronism (PHA). To further support the diagnosis of PHA, the urinary aldosterone/creatinine ratio was calculated both before and after oral administration of fludrocortisone acetate (0.05 mg/kg q 12 hr for 4 consecutive days). The urinary aldosterone/creatinine ratio was 92.6 × 10(-9) before fludrocortisone administration and 155.8 × 10(-9) 4 days later. Absence of suppression was typical of PHA. The cat had a limited response to antihypertensive medication and died before treatment for PHA could be instituted. A necropsy was not permitted by the owner.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26355586/