Peer-reviewed veterinary case report
Urine test shows high adrenaline markers in dogs with adrenal tumor
By Kook, P H et al.·Published in The Veterinary record·2010·Clinic for Small Animal Internal Medicine·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Urinary catecholamine and metadrenaline to creatinine ratios in dogs with a phaeochromocytoma.
- Species:
- dog
Plain-English summary
A group of dogs with a confirmed adrenal tumor called phaeochromocytoma had their urine tested for certain hormones. The results showed that these dogs had much higher levels of normetadrenaline compared to healthy dogs, indicating a potential way to diagnose this condition. The urine samples were collected at different times, and the dogs with more severe cases had the highest hormone levels. This information could help veterinarians identify and treat dogs with this type of tumor more effectively.
People also search for: dog adrenal tumor symptoms · phaeochromocytoma diagnosis in dogs · high hormone levels in dog urine
Abstract
Urinary adrenaline (epinephrine), noradrenaline, dopamine, metadrenaline (metanephrine) and normetadrenaline to creatinine ratios were measured from spot samples of seven client-owned dogs with a histologically confirmed phaeochromocytoma. Urine was collected on day 0 in the hospital in six dogs, and additionally on days 2, 6 and 7 after discharge in two of these dogs. In one dog, urine was sampled on day 7 only. Samples were also collected from 10 healthy control dogs on days 0, 1 and 7. In dogs with phaeochromocytomas, normetadrenaline:creatinine ratios at all time points ranged from 103 to 6430 nmol/mmol. From day 0, ratios of samples taken at the hospital (range 157 to 925 nmol/mmol) were significantly higher (P<0.0012) compared with control samples (range 14 to 91 nmol/mmol). The highest normetadrenaline:creatinine ratios were found in two dogs with bilateral phaeochromocytomas. Adrenaline:creatinine and noradrenaline:creatinine ratios were also significantly increased (P<0.016) in dogs with a phaeochromocytoma at day 0 compared with controls, although the difference was less pronounced than that between controls and dogs with a phaeochromocytoma for the normetadrenaline:creatinine ratio. Urine normetadrenaline:creatinine ratios may be useful in the diagnosis of canine phaeochromocytomas.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20139380/