Peer-reviewed veterinary case report
Urinary D-amino acid profiles in cats with chronic kidney disease.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2024
- Authors:
- Kimura, Ren et al.
- Affiliation:
- Analytical Science Research Laboratories · Japan
- Species:
- cat
Abstract
Chronic kidney disease (CKD) is highly prevalent in domestic cats. This study aimed to compare urinary D-amino acid levels between control and CKD-afflicted cats as a novel noninvasive method for assessing CKD. Cats were divided into control and CKD stage II groups in accordance with the International Renal Interest Society guidelines. The urinary DL-amino acid levels of the cats were analyzed using chiral tandem liquid chromatography-tandem mass spectrometry, and their medical records were investigated. The CKD group had considerably lower urinary D-amino acid concentrations and enantiomeric ratios than the control group. The total urinary D-amino acid contents significantly correlated with blood parameters (creatinine and urea nitrogen). These findings may contribute towards the detection of CKD stage II in domestic cats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38853004/