Peer-reviewed veterinary case report
Urinary F-Isoprostanes Levels in Cats with Chronic Kidney Disease
By Whitehouse, W et al.·Published in Journal of veterinary internal medicine·2017·Department of Medical Sciences·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Urinary F-Isoprostanes in Cats with International Renal Interest Society Stage 1-4 Chronic Kidney Disease.
- Species:
- cat
Plain-English summary
A 6-year-old cat with chronic kidney disease (CKD) was studied to see if a specific marker of oxidative stress in urine, called F-isoprostanes, increased as the disease progressed. The results showed that while these markers were higher in early-stage CKD compared to healthy cats, they actually decreased in cats with more advanced stages of CKD. This suggests that oxidative stress might be different in early versus late stages of the disease. The researchers recommend further studies to explore if early treatment with antioxidants could help slow down the progression of CKD in cats.
People also search for: cat chronic kidney disease symptoms · cat kidney disease treatment · cat urine test results interpretation
Abstract
BACKGROUND: F-isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood. OBJECTIVES: To determine whether cats with advancing CKD have increasing urinary F-isoprostanes. ANIMALS: Control cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS stage 1 (n = 8), 2 (n = 38), 3 (n = 21), and 4 (n = 10) CKD. METHODS: This was a prospective observational study. Urinary F-isoprostanes (specifically free 15-F-isoprostanes) normalized to urine creatinine (IsoPs) were compared among groups and tested for correlations with blood pressure, proteinuria, serum creatinine concentration, and urine specific gravity. The IsoPs also were compared between cats with and without hypertension or proteinuria, and in cats fed predominantly standard versus renal diets. RESULTS: Urinary IsoPs were increased, but not significantly, in cats with stage 1 CKD (median 263 pg/mg creatinine; range, 211-380) compared to controls (182 pg/mg; range, 80-348) and decreased significantly from stage 1 through advancing CKD (stage 2, 144 pg/mg; range, 49-608; stage 3, 102 pg/mg; range, 25-158; stage 4, 67 pg/mg; range, 26-117; P < .01). Urinary IsoPs were inversely correlated with serum creatinine (r = -0.66, P < .0001). CONCLUSION AND CLINICAL IMPORTANCE: Urinary IsoPs are significantly higher in early CKD (stage 1) compared to cats with more advanced CKD. Additional studies are warranted to characterize oxidative stress in cats with stage 1 CKD and determine whether early antioxidant treatments have a protective effect on CKD progression.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28160524/