Peer-reviewed veterinary case report
Urinary heat shock protein-72 as a kidney disease marker in cats
By Chen, H et al.·Published in Veterinary journal (London, England : 1997)·2019·Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Urinary heat shock protein-72: A novel marker of acute kidney injury and chronic kidney disease in cats.
- Species:
- cat
Plain-English summary
A group of cats with kidney issues were tested for a new marker called urinary heat shock protein-72 (uHSP72) to see if it could help diagnose acute kidney injury (AKI) and predict outcomes in chronic kidney disease (CKD). The study found that cats with AKI had significantly higher levels of uHSP72 compared to healthy cats, making it a useful tool for early diagnosis. Additionally, cats with CKD who had lower levels of uHSP72 tended to live longer than those with higher levels. This suggests that uHSP72 could be an important marker for both diagnosing kidney problems and assessing the prognosis in affected cats.
People also search for: cat kidney disease symptoms · cat acute kidney injury treatment · urinary heat shock protein in cats · chronic kidney disease in cats prognosis
Abstract
Acute kidney injury (AKI) in cats is associated with high mortality, partially attributed to late recognition of the disease when using currently available markers. Feline chronic kidney disease (CKD) has a variable progression rate. This study aimed to evaluate the sensitivity and specificity of urinary heat shock protein-72 to urinary creatinine ratio (uHSP72:uCr) as a diagnostic and prognostic marker in feline AKI, and as a prognostic indicator in feline CKD. The study included 63 cats, divided into five groups: healthy controls (n=10), urethral obstruction (UO; n=7), CKD (n=15), AKI (16 cats) and acute decompensating CKD (ACKD; n=15). Median uHSP72:uCr (ng/mg) of healthy, UO, CKD, AKI and ACKD cats were 0.44 (range, 0.13-1.1), 1.96 (range, 0.64-11.9), 4.2ng/mg (range, 0.57-22.16), 3.2 (range, 0.42-10.91) and 7.0 (range, 1.2-20.96), respectively, and differed (P<0.001) among groups. uHSP72:uCr was significantly lower in the controls vs. the CKD, AKI and ACKD groups. Receiver operator characteristic analysis of uHSP72:uCr, including the AKI and control groups, showed an area under the curve of 0.93 (95% confidence interval, 0.84-1.00), indicating an excellent predictive performance for diagnosing AKI. A 0.54ng/mg cutoff point corresponded to 94% sensitivity and 70% specificity for diagnosing AKI. The median survival time of cats with CKD with low uHSP72:uCr was longer (P=0.036) than in those with high uHSP72:uCr (561 vs. 112 days, respectively). uHSP72:uCr is a highly sensitive, moderately specific marker of AKI in cats, and is associated with the survival of cats with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30606443/