Peer-reviewed veterinary case report
Urine marker levels in dogs under isoflurane or sevoflurane anesthesia
By Harris S et al.·2024·Department of Clinical Sciences, United States·View original on Europe PMC →
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Original publication title: Urinary syndecan-1 in dogs anesthetized with isoflurane or sevoflurane: A randomized, prospective study.
- Species:
- dog
Plain-English summary
A group of 31 dogs undergoing anesthesia for MRI, some with suspected intervertebral disk disease (IVDD), had their urine tested before and after anesthesia with either sevoflurane or isoflurane. The results showed that the levels of a specific marker in their urine increased after anesthesia, indicating changes in their body during the procedure. The amount of IV fluids given to the dogs was found to significantly influence these changes. This suggests that the type and amount of fluids used during anesthesia could affect kidney function markers in dogs.
People also search for: dog anesthesia effects · IV fluids during dog surgery · intervertebral disk disease treatment in dogs
Abstract
<h4>Background</h4>Syndecan-1 (SDC1) is an established marker of endothelial glycocalyx shedding. Most research on SDC1 has focused on plasma or serum concentrations, and little is known about urine concentrations.<h4>Objectives</h4>Measure urinary SDC1 concentrations in dogs undergoing anesthesia with either sevoflurane or isoflurane and assess the effects of anesthesia duration and IV crystalloids on urinary SDC1 concentrations.<h4>Animals</h4>Thirty-one client-owned dogs undergoing anesthesia for magnetic resonance imaging (MRI) with or without surgery for suspected intervertebral disk disease (IVDD) were used.<h4>Methods</h4>Dogs with suspected IVDD were randomized to undergo anesthesia with either sevoflurane or isoflurane. Urine was collected before and immediately after anesthesia for the analysis of SDC1. Urinary creatinine concentrations also were measured, and the ratio of urinary SDC1 to urinary creatinine (USCR) was used to account for dilution.<h4>Results</h4>Median (range) USCR was significantly higher after anesthesia compared with baseline for all groups combined (P < .05). No significant difference was found between the groups for age, sex, weight, and type of anesthesia. Multiple regression analysis of the effect of the independent variables inhalant type, age, weight, sex, anesthesia time, surgery, and quantity of IV fluids on the dependent variable SDC1 found that only the quantity of IV fluids significantly predicted a change (P < .001).<h4>Conclusions and clinical importance</h4>The total volume of lactated Ringer's solution administered to anesthetized dogs may affect USCR. Further investigations are warranted to evaluate the relationship between IV fluids and SDC1.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/38813802