Peer-reviewed veterinary case report
Protein in urine in dogs with pituitary hyperadrenocorticism
By Douglas S. Caragelasco et al.·Published in Pesquisa Veterinária Brasileira·View original on DOAJ →
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Original publication title: Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane
- Species:
- dog
Plain-English summary
A group of nine dogs with pituitary-dependent hyperadrenocorticism (a condition causing excessive cortisol) were monitored while being treated with a medication called trilostane. The study looked at their urine to check for protein levels, which can indicate kidney damage. Over six months, the dogs showed signs of kidney issues, specifically with low molecular weight proteins in their urine, suggesting that their kidneys were not functioning properly. The findings suggest that regular urine tests can help veterinarians assess kidney health in dogs with this condition and guide treatment decisions.
People also search for: dog hyperadrenocorticism treatment · trilostane for dogs · dog kidney disease symptoms
Abstract
ABSTRACT: Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/s0100-736x2017000700014