Peer-reviewed veterinary case report
Urine protein and enzyme levels in cats with idiopathic cystitis
By Panboon, Isadee et al.·Published in Journal of feline medicine and surgery·2017·1 Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Urine protein, urine protein to creatinine ratio and N-acetyl-β-D-glucosaminidase index in cats with idiopathic cystitis vs healthy control cats.
- Species:
- cat
Plain-English summary
A group of cats with idiopathic cystitis (a bladder condition causing inflammation) had significantly higher levels of protein in their urine compared to healthy cats. The study found that the urine protein levels were four times higher and the urine protein to creatinine ratio was five times higher in the affected cats. Additionally, a specific enzyme index related to bladder health was also elevated in these cats. This suggests that cats with this condition have notable changes in their urine that could help in understanding and managing their symptoms. Further research is needed to explore the implications of these findings.
People also search for: cat cystitis symptoms · cat urine protein levels · how to treat cat bladder inflammation
Abstract
Objectives The objective was to compare urine protein, urine protein to creatinine ratio (UPC) and N-acetyl-β-D-glucosaminidase (NAG) index between cats with idiopathic cystitis and clinically normal cats. Methods Urine and blood samples were collected from 19 clinically normal cats and 19 cats with idiopathic cystitis without azotaemia at the time of first presentation. Urine protein, urine creatinine and UPC were measured. Additionally, the urinary NAG concentration was measured using the colorimetric method, and the NAG index was calculated by dividing the urinary NAG concentration by the urine creatinine ratio. Results Urine protein concentration (mean ± SEM) was four times higher in cats with idiopathic cystitis (218.29 ± 58.95) than in clinically normal cats (56.13 ± 9.95) (P <0.05). The UPC (mean ± SEM) of cats with idiopathic cystitis (0.70 ± 0.19) was also five times higher than that of clinically normal cats (0.14 ± 0.02) (P <0.05). The mean ± SEM NAG index in cats with idiopathic cystitis (4.79 ± 1.53 U/g) was two times higher than that in clinically normal cats (2.14 ± 0.48 U/g). The log UPC was positively correlated with the log NAG index in cats with idiopathic cystitis at moderate levels (r= 0.512; P <0.05). Conclusions and relevance Cats with idiopathic cystitis had increased amounts of urine protein and an increased UPC. Further study is needed to address the role of urinary NAG and its relationship with glycosaminoglycan levels in cats with idiopathic cystitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27538869/