Peer-reviewed veterinary case report
Urine sodium levels after furosemide in dogs with heart failure
By Convey, Victoria et al.·Published in Journal of veterinary internal medicine·2024·Department of Clinical Sciences and Advanced Medicine, United States·View original on PubMed →
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Original publication title: Urine sodium concentration after intravenous furosemide in dogs with acute congestive heart failure and correlation with treatment efficacy.
- Species:
- dog
Plain-English summary
A group of 51 dogs with acute congestive heart failure (CHF) received intravenous furosemide, a common diuretic, to help relieve their symptoms. The study found that dogs with low urine sodium levels (uNa) took longer to respond to treatment and had fewer successful decongestion events compared to those with higher uNa levels. This suggests that measuring urine sodium can help veterinarians understand how well a dog is responding to diuretic treatment. By monitoring urine sodium, vets can better tailor treatment plans for dogs suffering from CHF.
People also search for: dog heart failure treatment · furosemide for dogs · urine sodium levels in dogs · congestive heart failure symptoms in dogs
Abstract
BACKGROUND: Poor natriuresis is a potential marker of diuretic resistance in dogs with acute congestive heart failure (CHF) but little is known about the relationship between urine sodium concentration (uNa) and frequency of successful decongestion. Supplemental Ois a common treatment in dogs with severe CHF. The time from start to discontinuation of supplemental Otherapy (DCSO) typically reflects the time course and ease of decongestion. HYPOTHESIS/OBJECTIVES: Urine Na concentration after IV administration of furosemide will be correlated with duration of treatment with supplemental O(time) and the cumulative frequency of successful DCSOduring hospitalization. ANIMALS: Fifty-one dogs with acute CHF. METHODS: Retrospective observational single center study. RESULTS: Dogs with low uNa had significantly longer mean timethan dogs with high uNa (uNa <87 mmol/L, 24.2 ± 2.6 hours vs uNa ≥87 mmol/L, 16.6 ± 1.7 hours; P = .02). Low uNa was correlated with lower cumulative frequency of DCSO(12 hour, 28%; 24 hour, 42%; 36 hour, 73%) compared to high uNa (12 hour, 28%; 24 hour, 88%; 36 hour, 96%; P = .005). History of PO loop diuretics, low serum chloride concentration (sCl), and high PCV were associated with low uNa. Urine Na concentration outperformed other metrics of diuretic responsiveness including weight loss. CONCLUSIONS AND CLINICAL IMPORTANCE: Urine Na concentration after IV furosemide predicted timeand cumulative frequency of DCSOin dogs with acute CHF, which likely reflects important aspects of diuretic responsiveness. Urine Na can assess diuretic responsiveness and treatment efficacy in dogs with CHF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38038223/