Peer-reviewed veterinary case report
Urinary function and hormone levels in spayed Beagles after GnRH
By Reichler, Iris Margaret et al.·Published in Theriogenology·2006·Clinic of Reproductive Medicine·View original on PubMed →
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Original publication title: Urodynamic parameters and plasma LH/FSH in spayed Beagle bitches before and 8 weeks after GnRH depot analogue treatment.
- Species:
- dog
Plain-English summary
A group of 10 spayed Beagle bitches with urinary incontinence were treated with a GnRH analogue (leuprolide) to see if it would help improve their bladder function. After 8 weeks, the dogs showed a significant increase in bladder capacity, meaning they could hold more urine before needing to go outside. However, the treatment did not change the pressure in the urethra or other measurements related to how well the urethra closed. This suggests that while the GnRH treatment helped with bladder function, it didn't affect the urethral pressure directly.
People also search for: spayed Beagle urinary incontinence treatment · GnRH for dog bladder issues · dog bladder capacity increase
Abstract
The pathophysiology of urinary incontinence due to spaying remains unknown. Incontinent bitches can be treated successfully with depot preparations of GnRH-analogues and there are differences in plasma gonadotropin levels between continent and incontinent spayed bitches. It is therefore assumed that the supraordinated hormones, GnRH, FSH, and/or LH, have an effect on the urodynamic parameters. In this study, the potential influence of these hormones on the lower urinary tract was investigated by measuring urethral pressure profiles and cystometry. Simultaneously, plasma concentrations in 10 spayed Beagle bitches were determined 5 weeks prior to and 8 weeks after treatment with the GnRH analogue leuprolide. Within 1 week of GnRH analogue administration, plasma FSH and LH levels decreased from 72.5 and 7.7 to 7.75 and 0.72ng/mL, respectively. These plasma gonadotropin levels correspond with those of intact bitches during anoestrus. Urethral pressure profiles indicated that the treatment had no significant effect on maximum urethral closure pressure, functional and total length of the urethra, or area of the closure pressure curve. The data obtained by cystometry regarding mean bladder threshold volume showed a significant increase from 109 to 172mL. The improvement in bladder function after the application of GnRH-application is presumably a direct effect of the GnRH as a relationship between the plasma gonadotropin levels and the urodynamic parameters could not demonstrated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16876857/