Peer-reviewed veterinary case report
Cats treated for feline infectious peritonitis developed urinary
By Allinder, Marissa et al.·Published in Journal of veterinary internal medicine·2024·Clinical Veterinary Pharmacy, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Uroliths composed of antiviral compound GS-441524 in 2 cats undergoing treatment for feline infectious peritonitis.
- Species:
- cat
Plain-English summary
An 8-month-old female cat and a 2-year-old male cat, both undergoing treatment for feline infectious peritonitis (FIP) with an antiviral medication called GS-441524, developed serious urinary issues. The younger cat experienced kidney problems and had stones in her urinary tract, which led to surgery to remove the stones and relieve a blockage. The older cat had trouble urinating and also required surgery to remove stones. Tests showed that the stones were mostly made up of the antiviral medication. Both cats were treated successfully, but more research is needed to help monitor cats on this medication for urinary stones.
People also search for: cat urinary stones treatment · FIP antiviral side effects · cat difficulty urinating after medication
Abstract
Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8-month-old female spayed domestic short-haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS-441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis. A 2-year-old male neutered domestic medium-haired cat undergoing treatment for confirmed FIP with GS-441524 developed dysuria (weak urine stream, urinary incontinence, and difficulty expressing the urinary bladder). This cat also was diagnosed sonographically with multifocal urolithiasis requiring temporary tube cystostomy after cystotomy and urolith removal. In both cases, initial urolith analysis showed unidentified material. Additional testing confirmed the calculi in both cats to be 98% consistent with GS-441524. Additional clinical studies are required to determine best screening practices for cats presented for urolithiasis during treatment with GS-441524.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38032049/