Peer-reviewed veterinary case report
Uromodulin gene variants linked to kidney and blood pressure in older
By Jepson, R E et al.·Published in The Journal of small animal practice·2016·Department of Clinical Sciences and Services·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study.
- Species:
- cat
Plain-English summary
A 14-year-old cat was studied to see if certain genetic variations could be linked to kidney function and blood pressure. Researchers looked at DNA from 227 older cats and found that four specific genetic changes were associated with higher blood pressure, but they did not find a connection to kidney disease or function. This suggests that genetics might play a role in blood pressure for cats, similar to what has been seen in humans. More research is needed to confirm these findings.
People also search for: cat high blood pressure symptoms · cat kidney disease genetics · older cat health monitoring
Abstract
OBJECTIVES: In humans, genome-wide association studies have identified variants in the uromodulin gene (UMOD) associated with blood pressure and renal function. This study aimed to evaluate the association of single nucleotide polymorphisms at the UMOD locus with renal function and blood pressure in cats. METHODS: We retrospectively identified cats aged 14 years that had participated in a geriatric monitoring program, and from which stored DNA samples were available, from a computerised database. We then measured the association of specific single nucleotide polymorphisms in the feline UMOD gene with renal function and systolic blood pressure as continuous variables and, also, the dichotomous outcome of azotaemic chronic kidney disease and systemic hypertension. RESULTS: Eight intronic single nucleotide polymorphisms, one 1372 base pairs upstream from UMOD and two exonic single nucleotide polymorphisms were evaluated in 227 cats with renal and blood pressure data. An analysis of 188 cats found four single nucleotide polymorphisms to be significantly associated (P<0·01) with systolic blood pressure although all were in linkage disequilibrium. No significant associations were identified between single nucleotide polymorphisms and renal function or chronic kidney disease. CLINICAL SIGNIFICANCE: Results of this pilot study suggest that genetic variation in UMOD might influence blood pressure in cats, similar to findings in humans. Validation of these results is required.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27699802/